Glycine dehydrogenase
| glycine dehydrogenase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| EC number | 1.4.1.10 | ||||||
| CAS number | 37255-40-6 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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In enzymology, a glycine dehydrogenase (EC 1.4.1.10) is an enzyme that catalyzes the chemical reaction
- glycine + H2O + NAD+
glyoxylate + NH3 + NADH + H+
The 3 substrates of this enzyme are glycine, H2O, and NAD+, whereas its 4 products are glyoxylate, NH3, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycine:NAD+ oxidoreductase (deaminating).
This should not be confused with:
the glycine dehydrogenase (decarboxylating), which is another name for the Glycine cleavage system P-protein (EC 1.4.4.2).
or the glycine dehydroganse (cyanide forming)(EC 1.4.99.5).
or the glycine dehydrogenase (cytochrome) (EC 1.4.2.1).
References
- GOLDMAN DS, WAGNER MJ (1962). "Enzyme systems in the mycobacteria. XIII. Glycine dehydrogenase and the glyoxylic acid cycle". Biochim. Biophys. Acta. 65 (2): 297–306. doi:10.1016/0006-3002(62)91048-X. PMID 13948749.